Lactobacilli are commensal bacteria that can regulate the microbiota and help to keep the balance of intestinal flora. Lactobacillus is gram-positive and a member of the lactic acid bacteria group. Some strains of Lactobacillus species may possess health promoting potential and are called as probiotics. The health benefits of lactobacilli can be ascribed to their interactions with the human gut, effects on the immune system and also direct interactions with the gut bacterial flora. However, not all lactobacilli behave the same and there are major differences between the strains and even within the species, implicating the importance of disease specific selection and design of probiotic combinations in order to achieve desired health inducing properties.
Our lactobacilli library
ImmuneBiotaTM is a collection of 150 unique and qualified lactobacilli strains. It is the starting point for selecting the appropriate multi-strain combinations for therapeutic effect. All strains can be used as food supplements without further safety evaluation as they are included in EFSA’s (European Food and Safety Authority) list of safe bacteria.
In vitro and in vivo selection platform
ImmuneBiotech has a strong scientific foundation, based on more than 15 years of research in immunology, inflammation, microbiology, gut-function and the microbiome. We have scientific methods and know-how to screen and combine strains in order to impact specific important problematic pathological alterations such as:
- gut microbiota/dysbiosis
- gut barrier functions
- immune system
There is growing evidence on the importance of the gut microbiota in several challenging diseases. In a healthy state the human microbiota should be diverse and hold some 1000 microbial species. However, antibiotic use and life-style factors including food habits and high stress-levels, often take a toll on the microbiota diversity creating a state of dysbiosis. Dysbiosis in now known to be involved in several diseases, ranging from gut infections, metabolic disorders, inflammatory conditions and even cancer. This might not be surprising as 80% of the body’s immune cells reside in the gut and also have to possibility to affect systemic conditions.
Gut barrier function
The primary function of the Gastrointestinal (GI) tract is to digest food and absorb nutrients as well as liquids and electrolytes. The GI epithelium is specialized for absorption while it simultaneously protects the body against all microorganism within the lumen. To do this the epithelial cells of the GI tract form a selectively permeable barrier that is tightly regulated. Both luminal and endogenous stimuli, e.g. nutrients, bacteria and inflammatory molecules, can affect the intestinal permeability. An increased intestinal permeability has been shown in different pathological complications and is suggested either as a cause or consequence of the disease.