Lactobacilli are commensal bacteria that can regulate the microbiota and help to keep the balance of intestinal flora. Lactobacillus is gram-positive and a member of the lactic acid bacteria group. Some strains of Lactobacillus species may possess health promoting potential and are called as probiotics. The health benefits of lactobacilli can be ascribed to their interactions with the human gut, effects on the immune system and also direct interactions with the gut bacterial flora. However, not all lactobacilli behave the same and there are major differences between the strains and even within the species, implicating the importance of disease specific selection and design of probiotic combinations in order to achieve desired health inducing properties.
Our lactobacilli library
Based on our unique skills and expertise in immunology and in the probiotic field we have been able to generate a library of well-characterized and unique lactobacilli strains. Our lactobacilli library serves as a research platform for selecting strains with desired immune modulatory and other disease specific properties.
In vitro and in vivo selection strategies
Depending on the desired therapeutic intervention we can identify lactobacilli strains that are either pro- or anti-inflammatory. We can also identify strains with inhibitory effects on other bacteria. This allows for the generation of several different types of lactobacilli combinations specifically designed for highest therapeutic potential in the targeted indications.
Examples of properties that can be modulated by the lactobacilli combinations are:
- gut microbiota/dysbiosis
- gut barrier functions
- immune system
There is growing evidence on the importance of the gut microbiota in several challenging diseases. In a healthy state the human microbiota should be diverse and hold some 1000 microbial species. However, antibiotic use and life-style factors including food habits and high stress-levels, often take a toll on the microbiota diversity creating a state of dysbiosis. Dysbiosis in now known to be involved in several diseases, ranging from gut infections, metabolic disorders, inflammatory conditions and even cancer. This might not be surprising as 80% of the body’s immune cells reside in the gut and also have to possibility to affect systemic conditions.
Gut barrier function
The primary function of the Gastrointestinal (GI) tract is to digest food and absorb nutrients as well as liquids and electrolytes. The GI epithelium is specialized for absorption while it simultaneously protects the body against all microorganism within the lumen. To do this the epithelial cells of the GI tract form a selectively permeable barrier that is tightly regulated. Both luminal and endogenous stimuli, e.g. nutrients, bacteria and inflammatory molecules, can affect the intestinal permeability. An increased intestinal permeability has been shown in different pathological complications and is suggested either as a cause or consequence of the disease.